Ozio Unveils Enhanced “Beauty Opener Serum Wrinkle & White” for Comprehensive Anti-Aging
Japan’s leading eggshell membrane extract serum has undergone a significant evolution. On January 7, 2026, Ozio Co., Ltd. launched a power-up renewal of its popular “Beauty Opener Serum Wrinkle & White” as a quasi-drug. This multi-functional serum, part of a series that has sold over 10 million units and reached 1.2 million users, now simultaneously addresses wrinkles, whitening, and anti-inflammation, while also working to combat loss of firmness.

Retaining its core strength of eggshell membrane extract and niacinamide for firmness, dark spots, and wrinkles, the updated formula introduces approximately 380 million ceramide liposomes per drop. This addition significantly boosts its penetration and moisturizing capabilities, making it a powerful ally for mature skin concerns.
Product Features and Enhancements
The Power of Eggshell Membrane for Youthful Skin
At the heart of the serum is eggshell membrane extract, incorporated at a high concentration of 90%. This natural ingredient is rich in 18 types of amino acids, collagen, hyaluronic acid, and proteoglycans—all vital components closely linked to Type III collagen, abundant in baby skin. This high concentration works to replenish moisture, enhancing firmness and radiance.
Triple-Action Care for Damaged Skin
Targeting common signs of aging, the serum features niacinamide, a medicinal active ingredient recognized for its wrinkle-improving effects. It helps to smooth out skin surface irregularities, reducing the appearance of wrinkles, and stimulates collagen production in the dermis to promote firmer skin. Niacinamide also offers whitening benefits by inhibiting melanin production, thus preventing dark spots and maintaining a brighter, clearer complexion. Furthermore, dipotassium glycyrrhizate, another medicinal active ingredient, helps prevent skin inflammation, contributing to a healthy and translucent skin appearance.

Enhanced Hydration and Delivery System
The revamped formula introduces approximately 380 million ceramide liposomes per drop. These tiny vesicles, structurally similar to skin, help to fortify the skin’s barrier function, protecting against moisture evaporation and external irritants, thus preventing dryness. Additionally, the serum utilizes Nicosome® for superior penetration, ensuring that the eggshell membrane extract and other hydrating and firming ingredients reach deep into the stratum corneum, promoting a fresh, moisturized complexion.
For more details on the product, visit: https://ozio.jp/lp/bosw/bosw_tk_001.html
How to Incorporate into Your Skincare Routine
This serum can be used both morning and night. After cleansing, simply remove the small cap, dispense 1-3 drops (about the size of a 1-yen coin) onto your palm, and gently spread it over your entire face. Finish by gently pressing your palms over your face to help the serum settle. For areas of particular dryness, a second application is recommended.

A Legacy of Innovation and Global Recognition
Ozio’s commitment to developing anti-aging products has driven its stable growth in a flourishing market. The company aims to meet the evolving needs of consumers in the anti-aging sector, especially with the continued trend of wrinkle improvement, by enhancing popular products like this serum. Since its launch in 2015, the Beauty Opener series, featuring eggshell membrane extract, has been embraced by 1.2 million users.
The “Beauty Opener Serum Wrinkle & White” has earned the prestigious ‘S+ Grade’ from the Japan Eggshell Membrane Association, signifying the highest quality in ingredient sourcing, safety, and manufacturing hygiene. This recognition underscores the product’s commitment to excellence.

In a recent display of its growing international appeal, Ozio hosted a pop-up event at Starfield COEX Mall in Seoul, Korea, on October 14, 2025. The event garnered significant attention as a high-performance Japanese skincare brand, drawing numerous visitors and 24 influential Korean beauty influencers. Their positive feedback and social media buzz highlight the serum’s global resonance.

Professor Junko Atomi, a leading expert in eggshell membrane research and an Honorary Professor at the University of Tokyo, has dedicated her work to studying the skin benefits of eggshell membrane, with her findings published in American scientific journals. Her pioneering research provides a strong scientific foundation for the efficacy of this key ingredient.

This relaunch of a beloved Japanese beauty staple signals a continued dedication to advanced skincare. As Japanese beauty innovations increasingly captivate global audiences, the enhanced “Beauty Opener Serum Wrinkle & White” stands as a testament to the pursuit of effective and comprehensive anti-aging solutions, likely inspiring new trends in the international beauty landscape.


